Insulin receptors: structure and function.

E Van Obberghen; S Gammeltoft

doi:10.1007/978-3-0348-9291-9_3

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Insulin receptors: structure and function.

E Van Obberghen·S Gammeltoft

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Abstract

The recent characterization of the human insulin receptor structure and its intrinsic tyrosine kinase activity represent major advances in our understanding of the mechanism of insulin action. It is reasonable to think that the insulin-induced autophosphorylation and activation of its receptor kinase represent an important event in the action of insulin on cell metabolism and growth. The fundamental research reviewed may be followed by the discovery of molecular receptor defects in clinical syndromes of insulin resistance.

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Amino Acid Sequence Animals Humans Insulin Models, Biological Phosphorylation Protein-Tyrosine Kinases Receptor, Insulin Substrate Specificity Journal Article Research Support, Non-U.S. Gov't Review

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E Van Obberghen, S Gammeltoft. 1987. Insulin receptors: structure and function.. https://doi.org/10.1007/978-3-0348-9291-9_3

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