Interaction at a distance between lambda repressors disrupts gene activation.

A Hochschild; M Ptashne

doi:10.1038/336353a0

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Interaction at a distance between lambda repressors disrupts gene activation.

A Hochschild·M Ptashne

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Abstract

The lambda repressor is an activator as well as a repressor of transcription. The activation function is blocked by interaction with another lambda repressor molecule bound upstream on the same DNA molecule. This example of negative control at a distance involves formation of a DNA loop.

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Bacteriophage lambda Gene Expression Regulation Mutation Operon Promoter Regions, Genetic Repressor Proteins Transcription Factors Transcriptional Activation Journal Article

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A Hochschild, M Ptashne. 1988-11-24. Interaction at a distance between lambda repressors disrupts gene activation.. https://doi.org/10.1038/336353a0

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