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Bone marrow morphologic changes after combination chemotherapy including VP-16.

D J Adelstein·J D Hines
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Abstract

Bone marrow aspirates and biopsy specimens were examined from seven patients with small cell lung cancer. All patients had received recent combination chemotherapy including VP-16. No correlation between marrow biopsy cellularity and hematologic toxicity could be established. However, an unusual combination of morphologic changes was seen. This included an initial rapid increase in the M:E ratio, interference with cell division, and eventual cell death. There was little evidence of mitotic arrest or megaloblastosis. These changes are consistent with the known mechanism of action of VP-16, the only agent given to all patients. The small sample size and the unknown contributions of the other cytotoxic agents administered allow only limited conclusions.

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Antineoplastic Combined Chemotherapy ProtocolsBone MarrowCarcinoma, Small CellCyclophosphamideDoxorubicinErythrocytesEtoposideFemaleHematopoiesisHumansLung NeoplasmsMaleMitosisPodophyllotoxinVincristineJournal Article

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D J Adelstein, J D Hines. 1985-08-01. Bone marrow morphologic changes after combination chemotherapy including VP-16.. https://doi.org/10.1002/1097-0142(19850801)56%3A3%3C467%3A%3Aaid-cncr2820560309%3E3.0.co%3B2-0

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