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PubMed · 2989601

Multiple cutaneous papillomas and carcinomas that develop spontaneously in a mouse mutant, the repeated epilation heterozygote Er/+.

M A Lutzner·J L Guenet·F Breitburd
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Abstract

After a chance observation that multiple cutaneous papillomas and squamous cell carcinomas occurred in 2 adult mice heterozygous for the repeated epilation gene Er, we surveyed a panel of 10 +/+ (wild type) and 30 Er/+ (heterozygous) mice from birth to over 2 years of age. Homozygous Er/Er mice could not be included since their defect is lethal at birth. Whereas no cutaneous tumors developed in the +/+ mice, 20 of the Er/+ mice, males and females, had developed 1-5 cutaneous papillomas and at least 1 cutaneous invasive squamous cell carcinoma by 2 years of age. No lesions were seen in mice younger than 6 months old. Although almost all Er/+ mice died with their tumor burden, no metastases have yet been proven histologically. The Er/+ mouse should serve as a useful model for the exploration of genetic factors in cutaneous squamous cell carcinomas in humans.

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AlopeciaAnimalsAntigens, ViralCarcinoma, Squamous CellDNA, NeoplasmDNA, ViralEpidermal Growth FactorFemaleGenes, LethalHeterozygoteMaleMiceMice, Mutant StrainsNeoplasms, Multiple PrimaryPapillomaviridaeRodent DiseasesSkin NeoplasmsJournal ArticleResearch Support, Non-U.S. Gov't

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M A Lutzner, J L Guenet, F Breitburd. 1985. Multiple cutaneous papillomas and carcinomas that develop spontaneously in a mouse mutant, the repeated epilation heterozygote Er/+.. https://pubmed.ncbi.nlm.nih.gov/2989601/

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