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beta-Endorphin: surface binding and internalization in thymoma cells.

L Schweigerer·W Schmidt·H Teschemacher·C Gramsch
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Abstract

The opioid peptide beta-endorphin binds to specific nonopioid binding sites (Mr 72,000) that are present on the surface of thymoma cells. beta-Endorphin is then internalized, apparently via the Mr 72,000 species, and is subsequently found within intracellular, vesicular structures. This process is accompanied by the down-regulation of the Mr 72,000 binding sites. Our findings suggest that beta-endorphin may modulate cellular functions, such as T-lymphocyte proliferation, at intracellular rather than cell surface sites.

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AnimalsCell LineEndocytosisEndorphinsHydrogen-Ion ConcentrationKineticsMiceReceptors, OpioidThymomaThymus Neoplasmsbeta-EndorphinJournal ArticleResearch Support, Non-U.S. Gov't

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L Schweigerer, W Schmidt, H Teschemacher, C Gramsch. 1985. beta-Endorphin: surface binding and internalization in thymoma cells.. https://doi.org/10.1073/pnas.82.17.5751

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