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Bioreactions at the tissue/hydroxyapatite interface.

C A van Blitterswijk·J J Grote·W Kuÿpers·C J Blok-van Hoek·W T Daems
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Abstract

The events at the hydroxyapatite implant material/tissue interface in the rat middle ear were studied by light microscopy, autoradiography, morphometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray microanalysis. Deposition of calcium, partially in the form of calcium phosphate, was found at the interface. Resorption of the implant material occurred as the result of mono- and multinuclear phagocyte activity. Resorption decreased 6 mnth after the operation, possibly due to the decreasing number of phagocytes at the interface and the increasing amount of bone in the macropores.

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AnimalsBiodegradation, EnvironmentalCalciumDurapatiteEar, MiddleElectron Probe MicroanalysisHydroxyapatitesMacrophagesMaleMicroscopy, ElectronMicroscopy, Electron, ScanningPhagocytosisProstheses and ImplantsRatsRats, Inbred StrainsJournal ArticleResearch Support, Non-U.S. Gov't

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C A van Blitterswijk, J J Grote, W Kuÿpers, C J Blok-van Hoek, W T Daems. 1985. Bioreactions at the tissue/hydroxyapatite interface.. https://doi.org/10.1016/0142-9612(85)90020-1

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