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PubMed · 2999027

Togaviridae.

E G Westaway·M A Brinton·Gaidamovich SYa·M C Horzinek·A Igarashi·L Kääriäinen·D K Lvov·J S Porterfield·P K Russell·D W Trent
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Abstract

The family Togaviridae comprises four genera: Alphavirus (with 26 species), Rubivirus (one species), Pestivirus (three species), and Arterivirus (one species). The main characteristics of the member viruses are: (i) the virus particles are spherical, 50-70 nm in diameter, including an envelope with surface projections that incorporate two or three polypeptides, usually glycosylated; (ii) the nucleocapsid comprises a core protein and a single strand of positive-sense RNA, molecular weight about 4 X 10(6); where characterized, the RNA has an m7G 'cap' at the 5' end and is polyadenylated at the 3' end; (iii) maturation occurs by budding of spherical nucleocapsids 30-35 nm in diameter, with proven or presumed icosahedral symmetry, through cytoplasmic membranes. Where characterized, translation of structural proteins occurs on subgenomic messenger RNA(s); these appear to represent the 3' end of the genome. Nearly all alphavirus species are transmitted by mosquitoes. Transmission also occurs transovarially (Alphavirus) or transplacentally (Rubivirus and Pestivirus). Members of a genus are serologically related, but are not related to members of other genera.

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AlphavirusAnimalsAntigens, ViralFlavivirusGenes, ViralPestivirusSpecies SpecificityTogaviridaeTogaviridae InfectionsViral ProteinsVirus ReplicationJournal ArticleReview

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E G Westaway, M A Brinton, Gaidamovich SYa, M C Horzinek, A Igarashi, L Kääriäinen, D K Lvov, J S Porterfield, P K Russell, D W Trent. 1985. Togaviridae.. https://doi.org/10.1159/000149632

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