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PubMed · 3000391

Interleukin 2: a review.

J E Kolitz·K Welte·K W Sykora·R Mertelsmann
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Abstract

Interleukin 2 (IL 2) is a central mediator of the growth and functional activity of B- and T-cells, and cytotoxic cells, including Natural Killer and Lymphokine Activated Killer cells. Significant defects in the production of, and response to, IL 2 have been described in a variety of congenital and acquired immunodeficiency states. IL 2 has demonstrated major anti-tumor activity in animal models. The biochemistry and molecular biology of IL 2 and its gene are reviewed, along with data regarding the IL 2 receptor, normal T-cell activation, abnormalities in IL 2 production and response in immunodeficiency states and leukemia, and initial explorations of IL 2 in the treatment of human cancer.

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Acquired Immunodeficiency SyndromeAmino Acid SequenceAnimalsAntibodies, MonoclonalClone CellsDNA Restriction EnzymesHumansInterleukin-2KineticsLeukemiaLymphocyte ActivationMembrane ProteinsNeoplasmsOligonucleotidesRNA, MessengerReceptors, ImmunologicReceptors, Interleukin-2T-LymphocytesJournal ArticleReview

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J E Kolitz, K Welte, K W Sykora, R Mertelsmann. 1985. Interleukin 2: a review.. https://pubmed.ncbi.nlm.nih.gov/3000391/

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