PubMed · 3000481
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
S N Wolff. 1986. Epstein-Barr genomes.. https://pubmed.ncbi.nlm.nih.gov/3000481/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
Hepatitis B virus (HBV) mutants have recently been identified in patients with acute and chronic HBV infection. They accumulate during the natural course of infection and may eventually constitute the major or only viral species. Mutations have been detected in all viral genes (except the X-gene) and may be associated with a specific clinical course of the infection, e.g., chronic active or fulminant hepatitis. The exact contribution of mutations to the natural clinical course of HBV infection remains to be established, however.
A viral double-stranded (ds)RNA associated with reduced virulence (hypovirulence) and the accompanying biological control of the chestnut blight fungus, Cryphonectria parasitica, was shown recently to contain two contiguous coding domains designated ORF A and ORF B. We report here that transformation of an isogenic virulent, dsRNA-free C. parasitica strain with a cDNA copy of ORF A conferred traits similar to those exhibited by the dsRNA-containing hypovirulent strain: characteristics included reduced pigmentation, reduced laccase accumulation and suppressed conidiation. However virulence was not reduced, indicating an apparent uncoupling of associated traits from hypovirulence. These results establish a direct cause and effect relationship between a viral dsRNA genetic element present in a hypovirulent C. parasitica strain and specific phenotypic traits. They demonstrate further that these traits are not the result of a general reaction of the fungus to the presence of the replicating viral RNA, but are caused by a specific viral coding domain.