Hexacarbon neuropathy: tracking a toxin.

D Couri; M M Milks

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PubMed · 3003628

Hexacarbon neuropathy: tracking a toxin.

D Couri·M M Milks

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Abstract

This paper will present the progression of hexacarbon studies which followed the investigation of circumstances surrounding the occurrence of peripheral neuropathy in an occupational setting. The identification of methyl n-butyl ketone as the neurotoxin led to systematic studies of the biotransformation and mechanism of neurotoxicity. A consistent line of evidence showed that the neurotoxic potential of hexacarbons is directly related to the formation of the gamma-diketone metabolite, 2,5-hexanedione. The precise nature of the chemical interaction at the neurofilament is the subject of continuing investigation.

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Animals Biotransformation Hexanes Hexanones Humans Intermediate Filament Proteins Isomerism Ketones Methyl n-Butyl Ketone Neurofilament Proteins Occupational Diseases Peripheral Nervous System Diseases Pyrroles Rats Textile Industry Journal Article

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D Couri, M M Milks. 1985. Hexacarbon neuropathy: tracking a toxin.. https://pubmed.ncbi.nlm.nih.gov/3003628/

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