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PubMed · 3003852

Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition.

H Högström·U Haglund
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Abstract

Rats were subjected to end-to-end intestinal anastomosis. Breaking strength with the sutures in place, i.e., suture-holding capacity, was measured in different groups immediately after suture and after 24 h. The synthetic kallikrein-plasmin inhibitor S-2441, the inhibitor of plasminogen activation tranexamic acid (Cyklokapron), and the metalloprotease inhibitor tiopronin (Thiola), were studied regarding their effect on breaking strength of the intestinal anastomoses. There was a marked decrease in breaking strength at 24 h in the controls. This decrease was diminished by all of the substances tested. Their effect was probably due to an inhibition of collagenase.

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AnimalsMaleMicrobial CollagenaseOligopeptidesRatsRats, Inbred StrainsSuturesTensile StrengthTime FactorsTioproninTranexamic AcidJournal ArticleResearch Support, Non-U.S. Gov't

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H Högström, U Haglund. 1985. Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition.. https://doi.org/10.1007/bf01851851

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