Endothelium-derived relaxing factor (EDRF).

F V DeFeudis

doi:10.1007/bf01966589

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Endothelium-derived relaxing factor (EDRF).

F V DeFeudis

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Abstract

Recent studies on endothelium-dependent vasorelaxation have been briefly reviewed and analyzed. The following processes appear to subserve this mechanism: In the endothelial cell: receptor activation, activation of phospholipases, mobilization of intracellular Ca2+, synthesis and release of 'endothelium-derived relaxing factor(s) (EDRF); In the smooth muscle cell: activation of guanyl cyclase and protein kinase, protein phosphorylation/dephosphorylation, relaxation. Alterations of this mechanism could be involved in certain cardiovascular disorders.

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Animals Cell Membrane Endothelium Enzyme Activation Humans Muscle, Smooth, Vascular Nitric Oxide Phospholipases Rabbits Receptors, Cell Surface Vasodilator Agents Journal Article Review

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F V DeFeudis. 1985. Endothelium-derived relaxing factor (EDRF).. https://doi.org/10.1007/bf01966589

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