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PubMed · 3020116

Sodium loading raises urinary cortisol in man.

G Wambach·C Bleienheuft·G Bönner
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Abstract

It has been suggested that cortisol secretion is modified by sodium intake. We therefore studied the pituitary-adrenal axis by measuring diurnal rhythms of ACTH and cortisol levels in serum of 10 normal control subjects after 4 days of low sodium diet (intake 40 mEq/day) and after 6 days of high sodium diet (intake 320 mEq/day). Urinary excretion of aldosterone-18-glucuronide and free cortisol were determined at the end of each diet. Urinary aldosterone excretion declined from 17.9 +/- 2.6 to 2.8 +/- 1.1 microgram/day and urinary cortisol increased from 26.2 +/- 6.2 to 36.8 +/- 13.8 micrograms/day during low and high sodium intake. In contrast, plasma ACTH and serum cortisol measured every two hours for a 24-h period were similar both during low and high sodium intake. The results suggest an altered handling of cortisol by the kidney during high salt intake.

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Adrenocorticotropic HormoneAdultAldosteroneCircadian RhythmDiet, Sodium-RestrictedFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemPotassiumSodiumJournal ArticleResearch Support, Non-U.S. Gov't

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G Wambach, C Bleienheuft, G Bönner. 1986. Sodium loading raises urinary cortisol in man.. https://doi.org/10.1007/bf03348113

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