Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose.

M D Chafetz; K Parko; S Diaz; S F Leibowitz

doi:10.1016/0006-8993(86)91182-0

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Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose.

M D Chafetz·K Parko·S Diaz·S F Leibowitz

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Abstract

These experiments examine the dependence of medial hypothalamic alpha 2-receptor binding on the availability of circulating glucose. Food deprivation and tolbutamide-induced hypoglycemia both diminished alpha 2-binding. These binding results were highly correlated with serum glucose levels. Prevention of tolbutamide hypoglycemia by concomitant injections of dextrose blocked the effects on alpha 2-binding. Injection of norepinephrine into the medial hypothalamic sites that normally elicit feeding behavior elevated serum glucose. These results suggest a homeostasis for control of glucose in a hypothalamic feeding system.

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Animals Blood Glucose Clonidine Female Food Deprivation Hypothalamus, Middle Male Norepinephrine Rats Rats, Inbred Strains Receptors, Adrenergic, alpha Tolbutamide Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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M D Chafetz, K Parko, S Diaz, S F Leibowitz. 1986-10-08. Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose.. https://doi.org/10.1016/0006-8993(86)91182-0

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