Binding experiment KD values and physiologically active GABA concentrations: an only apparent contradiction?

A Cupello; H Hydén

doi:10.3109/00207458608985681

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Binding experiment KD values and physiologically active GABA concentrations: an only apparent contradiction?

A Cupello·H Hydén

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Abstract

An apparent contradiction exists between GABAA receptor binding KD's (less than 10(-6) M) and GABA concentrations physiologically active in various systems (greater than 10(-6) M). Taking in account that synaptic cleft GABA action and removal should be rather quick (within 2 ms) we show that in principle there is no contradiction between low KD values (100-150 nM) and high physiologically active GABA concentrations (greater than 40 microM).

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Animals Brain Cats Cattle Cerebral Cortex Kinetics Rats Receptors, GABA-A Spinal Cord Synaptic Transmission gamma-Aminobutyric Acid Journal Article Research Support, Non-U.S. Gov't

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A Cupello, H Hydén. 1986. Binding experiment KD values and physiologically active GABA concentrations: an only apparent contradiction?. https://doi.org/10.3109/00207458608985681

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