Intraperitoneal chemotherapy and immunotherapy.

B E Wolf; P H Sugarbaker

doi:10.1007/978-3-642-83293-2_37

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Intraperitoneal chemotherapy and immunotherapy.

B E Wolf·P H Sugarbaker

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Abstract

1. The predictive model is validated empirically; a kinetic advantage for i.p. administration of certain antineoplastic drugs exist. 2. The concentrations achieved in the peritoneum are orders of magnitude greater than those found in the plasma, so rate-limiting systemic toxicities may be avoided. 3. The aspirin principle--if one is good, two are better--may not be applicable unless we can utilize this advantage to improve survival.

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Antineoplastic Agents Female Gastrointestinal Neoplasms Humans Immunotherapy Injections, Intraperitoneal Models, Biological Ovarian Neoplasms Journal Article Review

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B E Wolf, P H Sugarbaker. 1988. Intraperitoneal chemotherapy and immunotherapy.. https://doi.org/10.1007/978-3-642-83293-2_37

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