[The structure of ribosome decoding center].

A P Potapov

PubMed · 3054504

[The structure of ribosome decoding center].

Abstract

To develop the hypothesis of direct interaction between the ribosome and the codon-anticodon sugar-phosphate backbones the model of the ribosome decoding centre structure is proposed. The model is based on the structural complementarity between the protein beta-sheet and the narrow groove of double-stranded RNA. A right handed two-stranded antiparallel beta-sheet is the main structural element of the model. One peptide strand interacts with the codon sugar-phosphate backbone while the second interacts with the anti-codon sugar-phosphate backbone. These stereoregular structures interact between them forming a regular system of H-bonds. The model postulates a specific rule of repetition for some amino acids in both peptide strands. Analysis of known sequences of the E. coli ribosomal proteins indicates such boxes of repeated arginine in proteins S1, S10, S11, S14 and boxes of repeated glycine in proteins S5, S11, (L15. These proteins are discussed as candidates for forming the corresponding "arginine" or "glycine" beta-sheets of the decoding centre and interaction with the codon-anticodon pairs. The properties of such interactions are analysed as well.

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Amino Acid Sequence Base Sequence Codon Escherichia coli Models, Biological Molecular Sequence Data RNA, Double-Stranded RNA, Messenger Ribosomal Proteins Ribosomes Journal Article

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A P Potapov. [The structure of ribosome decoding center].. https://pubmed.ncbi.nlm.nih.gov/3054504/

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