Anti-idiotypes and transfusions.

W J Burlingham; H W Sollinger

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PubMed · 3059602

Anti-idiotypes and transfusions.

W J Burlingham·H W Sollinger

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Abstract

There is growing evidence for the existence of an idiotypic network in the mammalian response to alloantigens, in particular to MHC antigens. The direct evidence for induction of Ab-2 to particular donor HLA-specificities by DST is strong; in addition, there is recent evidence for Ab-2 to Ab-1 specific for constant regions of HLA-ABC antigens in the sera of multiply-transfused patients. On the other hand, evidence for induction of anti-TCR antibodies by DST is based primarily on functional specificity rather than biochemical evidence; the evidence available suggests that MLC BF induced by DST may be directed against V beta family or public idiotypes on recipient T cells, since the amount of inhibition obtained is weak and no evidence of "clonotypic" antibodies has been found in studies of T cell lines or lymphoblasts. Better molecular probes, including human monoclonal antibodies, T cell clones, and purified TCR are needed to screen for specific anti-idiotypes in transfused patients.

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Animals Antibodies, Anti-Idiotypic Blood Transfusion Histocompatibility Antigens Class I Humans Immunoglobulin Idiotypes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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W J Burlingham, H W Sollinger. 1988. Anti-idiotypes and transfusions.. https://pubmed.ncbi.nlm.nih.gov/3059602/

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