[Comparative risks and benefits of drugs. Methodological problems].

M Biscos-Garreau; M Girard

PubMed · 3063510

[Comparative risks and benefits of drugs. Methodological problems].

Abstract

A focalizing toxicity is defined here as a specific toxicity which attracts much of the attention devoted to the safety of a drug: the hematotoxicity of "second generation" antidepressants is a typical example of such toxicity. The way in which it is handled is frequently biased, whether this be related to its perception or its reporting; as a result, it hampers the process of assessing the risk/benefit ratio of drugs. An attempt is made here to sketch the principles and methods of the validation of safety data; antidepressants furnish various examples of the different points that we make. Finally, we insist upon the fact that assessment of drug risk/benefit ratio must be global and comparative.

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Animals Antidepressive Agents Drug Evaluation Drug Evaluation, Preclinical Humans Comparative Study English Abstract Journal Article Review

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M Biscos-Garreau, M Girard. [Comparative risks and benefits of drugs. Methodological problems].. https://pubmed.ncbi.nlm.nih.gov/3063510/

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