Ibopamine--how should it be used?

Abstract

Ibopamine is an orally effective derivative of dopamine capable of eliciting peripheral and renal vasodilating activity and positive inotropic action. The compound is a prodrug which is enzymatically converted by plasma and peripheral tissues esterases to epinine (N-methyldopamine) which is the active drug. Effective plasma epinine levels are readily achieved, producing the hemodynamic action for 4-6 h. Acute and chronic studies demonstrated an improvement in cardiac output and a reduction in pre- and afterload.