Immunologic complexity of lymphoblastic lymphoma.

T Grogan; C Spier; D P Wirt; M J Hicks; M Paquin; J Hutter; T Miller; C Rangel; L Richter; S Jones

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PubMed · 3086016

Immunologic complexity of lymphoblastic lymphoma.

T Grogan·C Spier·D P Wirt·M J Hicks·M Paquin·J Hutter·T Miller·C Rangel·L Richter·S Jones

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Abstract

Twelve patients with a histologic diagnosis of lymphoblastic lymphoma (LBL) were studied immunologically using the methodologic refinement of comparative serial section immunochemistry. By this means, we demonstrate complex LBL phenotypic profiles, revealing 3 major immunologic subtypes: immature T cell, 7 cases; intermediate or mature T cell, 3 cases; immature B cell (pre-pre-B), 2 cases. This phenotypic diversity challenges the basic belief that all LBL are the same. Our immature T-cell cases with frequent simultaneous Leu 2/3/6/9/CALLA/Tdt expression correspond to cortical thymic phenotypes; our mature T-cell phenotypes with Leu 9/la expression and absent L6/Tdt correspond either to medullary thymocytes or post-thymic T cells; our pre-pre-B phenotypes with simultaneous Tdt/CALLA/B4 expression correspond to common acute lymphocytic leukemia (ALL) phenotypes. Mature T-LBL phenotypes are similar to "novel" peripheral T-cell lymphoma phenotypes. Scant or absent Tdt expression in mature LBL is not an isolated antigenic change but a complete phenotypic profile difference from immature T-LBL. The major T- and B-cell phenotypes of LBL might have therapeutic significance. Treatment among LBL phenotypes may need to vary as with acute lymphocytic leukemia phenotypes. Further study is needed; in the meantime, comparative serial section immunotyping promises substantial utility in revealing the immunologic complexity of the lymphomas.

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T Grogan, C Spier, D P Wirt, M J Hicks, M Paquin, J Hutter, T Miller, C Rangel, L Richter, S Jones. 1986. Immunologic complexity of lymphoblastic lymphoma.. https://pubmed.ncbi.nlm.nih.gov/3086016/

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