Chromosomal loop anchorage sites appear to be evolutionarily conserved.

P N Cockerill; W T Garrard

doi:10.1016/0014-5793(86)81377-1

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Chromosomal loop anchorage sites appear to be evolutionarily conserved.

P N Cockerill·W T Garrard

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Abstract

We have previously identified a class of DNA sequence elements, termed matrix association regions (MARs), which specifically bind to nuclear matrices in vitro and are believed to be at the bases of chromosomal loops in vivo. Here we demonstrate that nuclear matrices prepared from the yeast Saccharomyces cerevisiae will specifically bind an MAR sequence derived from the mouse kappa light chain immunoglobulin gene. This suggests that both MAR sequences and their binding sites have been strongly evolutionarily conserved.

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Animals Binding Sites Cell Line Chromosomes DNA Immunoglobulin Light Chains Immunoglobulin kappa-Chains Mice Nucleic Acid Conformation Saccharomyces cerevisiae Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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P N Cockerill, W T Garrard. 1986-08-11. Chromosomal loop anchorage sites appear to be evolutionarily conserved.. https://doi.org/10.1016/0014-5793(86)81377-1

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