In vitro immune interferon induction during tumor evolution.

S Kohan; E S Lustig; A R Teyssié; M Tous; B Ayerra

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PubMed · 3098317

In vitro immune interferon induction during tumor evolution.

S Kohan·E S Lustig·A R Teyssié·M Tous·B Ayerra

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Abstract

In a syngeneic C3H mammary adenocarcinoma model we studied gamma-interferon (gamma IFN) production during tumor evolution. The IFN production was induced by soluble tumor extracts on spleen cell cultures from tumor-bearing mice. A low level of IFN production was found in culture supernatants from small tumor-bearing mice (tumor diameter less than 10 mm, 12-15 days of tumor evolution). In advanced stages of tumor growth (diameter more than 15 mm, 20 days or more of tumor evolution), this ability was lost.

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Adenocarcinoma Animals Cells, Cultured Hydrogen-Ion Concentration Immune Tolerance Interferon-gamma Mammary Neoplasms, Experimental Mice Mice, Inbred C3H Spleen Journal Article

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S Kohan, E S Lustig, A R Teyssié, M Tous, B Ayerra. 1986. In vitro immune interferon induction during tumor evolution.. https://pubmed.ncbi.nlm.nih.gov/3098317/

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