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PubMed · 3098946

Reversible valproate fulminant hepatic failure.

R B Colletti·T D Trainer·B R Krawisz
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Abstract

Valproate fulminant hepatotoxicity, usually fatal, is believed to be idiosyncratic and metabolic without an immunologic basis. There are no previous reports of a hypersensitivity reaction among numerous cases of fatal valproate fulminant hepatitis. Little is known about the electron microscopical features of valproate hepatitis. We report a case of reversible fulminant hepatitis attributable to valproate with clinical and histological characteristics of a hypersensitivity reaction. Electron microscopical findings included microvesicular steatosis with normal-appearing mitochondria.

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Chemical and Drug Induced Liver InjuryChildDrug HypersensitivityHumansLiverMaleValproic AcidCase ReportsJournal Article

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R B Colletti, T D Trainer, B R Krawisz. Reversible valproate fulminant hepatic failure.. https://doi.org/10.1097/00005176-198611000-00032

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Chemical and Drug Induced Liver Injury↗