PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 3103255

[Congenital hypothyroidism. Current viewpoints and developments].

M H Gons·T Vulsma·J J de Vijlder
View original source ↗Export metadata ↓

Abstract

Since 1978 neonatal screening on congenital hypothyroidism (CHT) is performed in The Netherlands. A combined T4 and TSH determination is used. This creates the possibility to detect secondary and tertiary hypothyroidism. The number of false-positive cases is relatively high. This number decreases by adjusting the method of screening. Recent studies show a CHT incidence of 1:2100 newborns. In about 25% of these cases the CHT appears to be transient. Proceeding from the screening on CHT several investigations presented in this review are in progress.

Explore related subjects

Congenital HypothyroidismHumansHypothyroidismInfant, NewbornMass ScreeningNetherlandsThyrotropinThyroxineThyroxine-Binding ProteinsEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M H Gons, T Vulsma, J J de Vijlder. 1986. [Congenital hypothyroidism. Current viewpoints and developments].. https://pubmed.ncbi.nlm.nih.gov/3103255/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Plasma total thyroxine and free thyroxine concentrations in congenital hypothyroidism before and during treatment.

AIMS: To examine the relation between plasma total thyroxine and free thyroxine in children with congenital hypothyroidism. METHODS: Regression analysis was performed on 114 cases on the paired total thyroxine and free thyroxine measurements taken from the same blood sample. Conversion equations were derived using structural relation models. RESULTS: A linear relation was found between log total thyroxine and log free thyroxine values. The regression slopes for values taken before treatment and values taken while patients were receiving replacement treatment were significantly different. CONCLUSIONS: The data suggest that there is a close association between total and free thyroxine in congenital hypothyroidism, but that the relation is changed by thyroid replacement treatment.

Congenital Hypothyroidism↗
PubMed1992

Comparison of epidemiological data on congenital hypothyroidism in Europe with those of other parts in the world.

The actual worldwide incidence of congenital hypothyroidism (CH) is based on the results of screening in parts of the world where screening is mandatory, i.e. most of Europe, USA, Canada, Cuba, Australia, New Zealand and Japan. In other parts of the world, some indications are given by the results of pilot studies. In Europe, mean overall incidence (1985-1990) for the countries included in our inquiry is 1/3801--in each country for the same period: Austria 1/3,930, Belgium 1/3,750, Czechoslovakia 1/6,037, Denmark 1/3,777, Finland 1/3,969, France 1/4,132, FRG 1/3,827, Greece 1/3,314, Hungary 1/5,632, Israel 1/3,152, Italy 1/3,150, The Netherlands 1/3,723, Norway 1/3,069, Portugal 1/3,139, Spain 1/3,216, Switzerland 1/3,913, UK 1/3,398 and Turkey (pilot study 1989-1992) 1/2,943. In comparison, the figures for the USA for the whole country are similar for the mean overall incidence (1988-1990): 1/4,119. But large variations exist between the states, the reasons of which are perhaps related either to technical problems or to the ethnic background in each state. In Canada and Japan, modifications of screening procedures have led to similar figures for the last years in our possess, Canada (1986-1988) 1/3,884 and Japan (1990) 1/3,856. The figures (mean overall incidence) for Cuba (1987-1991) 1/2,325, for Australia (1985-1990) 1/1/3,331 and for New Zealand (1987-1990) 1/4,496 are quite comparable. So in these countries where the screening is established, no great variations are noted as in certain parts of the world with pilot studies: Argentine (Buenos Aires; 1985-1990) 1/4,407, Chile (1991-1992) 1/2,514, Brazil (Porto Alegre; 1987-1991) 1/4,429.(ABSTRACT TRUNCATED AT 250 WORDS)

Congenital Hypothyroidism↗