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PubMed · 3103493

Transfer from immediate-release disopyramide to controlled-release disopyramide.

D M DiPersio·M S Chow
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Abstract

Simulation of serum disopyramide concentrations during transfer from steady-state immediate-release (IR) disopyramide to a sustained-release disopyramide preparation was performed based on pharmacokinetic parameters obtained from IR disopyramide and serum concentrations measured following an initial dose of controlled-release (CR) disopyramide phosphate. Based on the results of simulation, a typical patient with good cardiac, renal, and hepatic function can be transferred from a q 6 h IR disopyramide to an equivalent daily dose of controlled-release disopyramide administered q 12 h beginning at 6 hours after the final IR disopyramide dose.

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Anti-Arrhythmia AgentsDelayed-Action PreparationsDisopyramideHumansKineticsJournal Article

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BibTeXRIS

D M DiPersio, M S Chow. 1987. Transfer from immediate-release disopyramide to controlled-release disopyramide.. https://pubmed.ncbi.nlm.nih.gov/3103493/

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