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PubMed · 3107448

Glyburide-induced hepatitis.

R C Goodman·P J Dean·A Radparvar·A E Kitabchi
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Abstract

Drug-induced hepatotoxicity, although common, has been reported only infrequently with sulfonylureas. For glyburide, a second-generation sulfonylurea, only two brief reports of hepatotoxicity exist. Two patients with type II diabetes mellitus developed an acute hepatitis-like syndrome soon after initiation of glyburide therapy. There was no serologic evidence of viral infection, and a liver biopsy sample showed a histologic pattern consistent with drug-induced hepatitis. Both patients recovered quickly after stopping glyburide therapy and have remained well for a follow-up period of 1 year. Glyburide can produce an acute hepatitis-like illness in some persons.

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BiopsyChemical and Drug Induced Liver InjuryFemaleGlyburideHumansLiverLiver Function TestsMiddle AgedCase ReportsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R C Goodman, P J Dean, A Radparvar, A E Kitabchi. 1987. Glyburide-induced hepatitis.. https://doi.org/10.7326/0003-4819-106-6-837

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