Practical considerations in establishing valid and sensitive neurobehavioral test methods.

H A Tilson

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PubMed · 3124371

Practical considerations in establishing valid and sensitive neurobehavioral test methods.

H A Tilson

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Abstract

Validity and Sensitivity are discussed as key concepts for the Evaluation of neurobehavioral tests; validity refers to the meaning of an observed behavioral change, and sensitivity to the capability of a test to detect behavioral changes relative to dose and/or to other tests. Examples are given to explain these concepts. It is proposed to validate tests by means of compounds with known neurotoxic properties, and to cover sensitivity by described dose-response characteristics.

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Animals Behavior, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical Drug-Related Side Effects and Adverse Reactions Nervous System Predictive Value of Tests Journal Article

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H A Tilson. 1987. Practical considerations in establishing valid and sensitive neurobehavioral test methods.. https://pubmed.ncbi.nlm.nih.gov/3124371/

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