Codon preference reflects mistranslational constraints: a proposal.

D T McPherson

doi:10.1093/nar/16.9.4111

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Codon preference reflects mistranslational constraints: a proposal.

D T McPherson

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Abstract

Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.

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Arginine Base Composition Codon Escherichia coli Lysine Protein Biosynthesis RNA, Messenger Journal Article

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D T McPherson. 1988-05-11. Codon preference reflects mistranslational constraints: a proposal.. https://doi.org/10.1093/nar%2F16.9.4111

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