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PubMed · 3131876

Interleukin-2: inception, impact, and implications.

K A Smith
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Abstract

Interleukin-2 (IL-2), the first of a series of lymphocytotrophic hormones to be recognized and completely characterized, is pivotal for the generation and regulation of the immune response. A T lymphocyte product, IL-2 also stimulates T cells to undergo cell cycle progression via a finite number of interactions with its specific membrane receptors. Because T cell clonal proliferation after antigen challenge is obligatory for immune responsiveness and immune memory, the IL-2-T cell system has opened the way to a molecular understanding of phenomena that are fundamental to biology, immunology, and medicine.

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Cell CycleInterleukin-2Lymphocyte ActivationReceptors, ImmunologicReceptors, Interleukin-2T-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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K A Smith. 1988-05-27. Interleukin-2: inception, impact, and implications.. https://doi.org/10.1126/science.3131876

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