LFA1 expression in HIV infection.

C Amiel; M C Béné; T May; P Canton; G C Faure

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PubMed · 3134916

LFA1 expression in HIV infection.

C Amiel·M C Béné·T May·P Canton·G C Faure

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Abstract

The expression of the adhesion molecule LFA1 was investigated in mononuclear cells from 200 samples of peripheral blood obtained from asymptomatic HIV-infected individuals and AIDS patients. The numbers and percentages of LFAI-positive cells were established by indirect immunofluorescence. A significant decrease in the number of labelled cells was observed (mean percentage 68.9) while 100% of the cells were positive in controls. These data suggest that LFA1-mediated cell-cell cooperation might be impaired in HIV infection, adding to the immune deficiency related to the disappearance of CD4+ cells.

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Acquired Immunodeficiency Syndrome Antigens, Differentiation, T-Lymphocyte Antigens, Surface Cell Communication Humans Lymphocyte Function-Associated Antigen-1 T-Lymphocytes, Cytotoxic Journal Article

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C Amiel, M C Béné, T May, P Canton, G C Faure. 1988. LFA1 expression in HIV infection.. https://pubmed.ncbi.nlm.nih.gov/3134916/

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