Thyroxine-binding globulin deficiency re-examined.

S Copping; P G Byfield

doi:10.1111/j.1365-2265.1988.tb01202.x

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Thyroxine-binding globulin deficiency re-examined.

S Copping·P G Byfield

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Abstract

Seven sera, previously categorised as completely deficient in thyroxine-binding globulin (TBG) by an immunoelectrophoretic technique, were re-examined with a sensitive ELISA method. Only one of the sera was confirmed completely deficient by ELISA. The remaining six contained 0.08-0.19 mg/l. The protein was immunologically identical with 'normal' TBG, could bind to thyroxine and had the correct mobility in reverse-flow electrophoresis. Complete TBG deficiency may therefore be rare.

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Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Humans Immunoelectrophoresis Male Thyroxine Thyroxine-Binding Proteins Journal Article

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S Copping, P G Byfield. 1988. Thyroxine-binding globulin deficiency re-examined.. https://doi.org/10.1111/j.1365-2265.1988.tb01202.x

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