PubMed · 31433
Potentiation of neostigmine and pyridostigmine by 4-aminopyridine in the rat.
Abstract
The interaction between 4-aminopyridine and neostigmine or pyridostigmine was studied in vivo in the rat sciatic nerve-anterior tibialis preparation using the constant infusion of pancuronium technique. The ED50 (dose of drug which produced a 50% antagonism) of neostigmine, pyridostigmine and 4-aminopyridine were 18, 49 and 440 microgram kg(-1) respectively. The addition of 100 microgram kg(-1) of 4-aminopyridine, which produced no antagonism by itself, decreased the neostigmine ED50 to 7.4 microgram kg(-1). The addition of 200 microgram kg(-1) of 4-aminopyridine, which produced a 30% antagonism by itself, decreased the ED50 of pyridostigmine to 11 microgram kg(-1). We conclude that both neostigmine and pyridostigmine interact with 4-aminopyrine synergistically.
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R D Miller, P A Dennissen, F van der Pol, S Agoston, L H Booij, J F Crul. 1978. Potentiation of neostigmine and pyridostigmine by 4-aminopyridine in the rat.. https://doi.org/10.1111/j.2042-7158.1978.tb13368.x
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