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G-proteins and egg activation.

L A Jaffe·P R Turner·D Kline·R T Kado·F Shilling
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Abstract

G-proteins are present in eggs, and experiments in which GTP-gamma-S, GDP-beta-S, cholera toxin and pertussis toxin have been injected into eggs have indicated the involvement of G-proteins in egg activation at fertilization and in oocyte maturation. Eggs into which serotonin or muscarinic acetylcholine receptors have been introduced by mRNA injection produce fertilization-like responses when exposed to serotonin or acetylcholine; since these neurotransmitter receptors act by way of G-proteins, this observation further supports the conclusion that a G-protein is involved in the fertilization process.

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AnimalsExocytosisFemaleFertilizationGTP-Binding ProteinsMaleOocytesOvumSea UrchinsSperm-Ovum InteractionsSpermatozoaJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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L A Jaffe, P R Turner, D Kline, R T Kado, F Shilling. 1988. G-proteins and egg activation.. https://doi.org/10.1016/0922-3371(88)90094-9

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