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Multidirectional interactions in an Mls-disparate response.

J Goldbach·H Kirchner·E Kölsch
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Abstract

The murine T cell clone E11, isolated from a primary H-2k-histocompatible, one-way mixed lymphocyte culture of B10.BR anti-C3H/Tif spleen cells, has been used to analyse multidirectional interactions in Mls-disparate responses. Several events can be observed. There is proliferation of T cells upon stimulation by macrophages or B cells of Mls-disparate stimulator cells. In addition, one finds induction of differentiation of B cells of stimulator strains. E11 T cells inhibit spreading and differentiation of macrophages of stimulator strains and also prevent the production of a T cell growth-supporting mediator by Mls-disparate spleen cells. All these phenomena can be explained by Mlsa,d,e-specific induction of gamma-interferon (gamma-IFN) production in the responder B10.BR (Mlsb) E11 T cells. It is suggested that gamma-IFN, as a regulator of feedback mechanisms, plays an essential role in Mls-disparate cell interactions.

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AnimalsAntigens, SurfaceB-LymphocytesCell CommunicationClone CellsInterferon-gammaLymphocyte ActivationMacrophagesMiceMice, Inbred StrainsMinor Lymphocyte Stimulatory AntigensT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov't

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J Goldbach, H Kirchner, E Kölsch. Multidirectional interactions in an Mls-disparate response.. https://doi.org/10.1111/j.1744-313x.1988.tb00416.x

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