An external stimulus that mimics Mls locus responses.

C A Janeway; J Chalupny; P J Conrad; S Buxser

doi:10.1111/j.1744-313x.1988.tb00418.x

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An external stimulus that mimics Mls locus responses.

C A Janeway·J Chalupny·P J Conrad·S Buxser

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Abstract

The response to a novel set of T cell mitogens has been analysed and compared to the response to Mls locus differences. These polyclonal T cell activators, staphylococcal enterotoxins A and B, stimulate T cells in a way that requires an antigen-presenting cell bearing class II MHC products and involves the CD4:T cell receptor complex. However, the specificity of MHC recognition by the T cell receptor is lost in this response. Thus, these mitogens produce a response with characteristics similar to that induced by Mls locus differences. These mitogens can be used to analyse the immunobiology of this response, and may help in understanding and identifying the Mls locus product as well.

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Animals Antigen-Presenting Cells Antigens, Differentiation, T-Lymphocyte Antigens, Surface B-Lymphocytes Clone Cells Enterotoxins Histocompatibility Antigens Class II In Vitro Techniques Lymphocyte Activation Mice Minor Lymphocyte Stimulatory Antigens Mitogens Receptors, Antigen, T-Cell T-Lymphocytes Tumor Cells, Cultured Journal Article Research Support, U.S. Gov't, P.H.S.

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C A Janeway, J Chalupny, P J Conrad, S Buxser. An external stimulus that mimics Mls locus responses.. https://doi.org/10.1111/j.1744-313x.1988.tb00418.x

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