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Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway.

C Reavill·N Leigh·P Jenner·C D Marsden
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Abstract

Extensive unilateral or bilateral electrolytic ablation of the rat superior colliculus failed to reduce apomorphine- or amphetamine-induced rotation in animals with a unilateral 6-hydroxydopamine lesion of one nigro-striatal dopaminergic pathway. These findings suggest that a nigro-tectal pathway does not play a crucial role in mediating the circling response caused by striatal dopamine receptor stimulation. However, electrolytic lesions of the dorsal tegmental decussation reduced apomorphine- but not amphetamine-induced rotation in such animals, perhaps by sectioning some commissural pathway between the two nigro-striatal systems.

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AnimalsApomorphineBehaviorCorpus StriatumDextroamphetamineDopamineEfferent PathwaysHumansHydroxydopaminesMaleMedial Forebrain BundleRatsReceptors, DopamineStereotyped BehaviorSubstantia NigraSuperior ColliculiJournal Article

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C Reavill, N Leigh, P Jenner, C D Marsden. 1979. Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway.. https://doi.org/10.1007/bf00237716

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