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Postradiation multicentric osteosarcoma.

C Tillotson·A Rosenberg·M Gebhardt·D I Rosenthal
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Abstract

The oncogenic effects of radiation are well-established. Osteosarcomas and fibrosarcomas are the two most common histologic types of secondary sarcoma. In this article a case of postradiation osteosarcoma is presented in which four discrete foci of sarcomatous transformation have occurred in the tibia and fibula after irradiation for a rhabdomyosarcoma of the calf 8 years earlier. A review of the literature reveals no similar case. Although synchronous, multifocal osteosarcoma without prior radiation has been described, this case differs in clinical, radiographic, and pathologic features; it best fits the description of postradiation multicentric osteosarcoma.

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Bone NeoplasmsChildFemaleFibulaHumansNeoplasms, Multiple PrimaryNeoplasms, Radiation-InducedOsteosarcomaRadiotherapyRhabdomyosarcomaTibiaCase ReportsJournal Article

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BibTeXRIS

C Tillotson, A Rosenberg, M Gebhardt, D I Rosenthal. 1988-07-01. Postradiation multicentric osteosarcoma.. https://doi.org/10.1002/1097-0142(19880701)62%3A1%3C67%3A%3Aaid-cncr2820620114%3E3.0.co%3B2-q

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