Viral myb oncogene encodes a sequence-specific DNA-binding activity.

H Biedenkapp; U Borgmeyer; A E Sippel; K H Klempnauer

doi:10.1038/335835a0

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Viral myb oncogene encodes a sequence-specific DNA-binding activity.

H Biedenkapp·U Borgmeyer·A E Sippel·K H Klempnauer

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Abstract

The retroviral oncogene v-myb and its cellular progenitor c-myb encode nuclear DNA-binding proteins. Myb genes have been identified in a broad range of species, including vertebrates, the fruit fly Drosophila melanogaster and the plant Zea mays. The localization of the DNA-binding domain of the v-MYB protein to the highly conserved amino-terminal region suggests that the MYB/DNA interaction is important for MYB function. We show here that v-MYB specifically recognizes the nucleotide sequence pyAACG/TG. So like other nuclear transforming proteins, v-MYB seems to be a member of the class of sequence-specific DNA-binding factors presumably involved in gene regulation.

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Base Sequence Binding Sites Cloning, Molecular DNA DNA-Binding Proteins Molecular Sequence Data Oncogene Proteins v-myb Oncogenes Plasmids Retroviridae Proteins Journal Article Research Support, Non-U.S. Gov't

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H Biedenkapp, U Borgmeyer, A E Sippel, K H Klempnauer. 1988-10-27. Viral myb oncogene encodes a sequence-specific DNA-binding activity.. https://doi.org/10.1038/335835a0

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