Heparin binding to normal and abnormal platelets.

M K Horne

doi:10.1016/0049-3848(88)90057-6

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Heparin binding to normal and abnormal platelets.

M K Horne

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Abstract

The binding of porcine heparin to human platelets was studied using [3H] heparin and various concentrations of unlabeled heparin. The binding was readily reversible and included saturable (Kd approximately 1.5 mg/L, R approximately 500 mg/10(15) cells) and unsaturable components. Approximately normal binding also occurred to platelets from patients with the Bernard-Soulier syndrome and Glanzmann's thrombasthenia. Competitive inhibition studies were performed with a variety of sulfated polysaccharides. Inhibitory potency correlated with charge density but not with the fundamental sugar composition of the tested compounds.

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Animals Bernard-Soulier Syndrome Binding, Competitive Blood Platelets Heparin Humans Swine Thrombasthenia Journal Article

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M K Horne. 1988-07-15. Heparin binding to normal and abnormal platelets.. https://doi.org/10.1016/0049-3848(88)90057-6

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