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PubMed · 3191634

Bone-cell-stimulating substance.

I Clark·J P Zawadsky·W Lin·R A Berg
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Abstract

An acid-pepsin extract of ground cancellous calf bone contains a bone-cell-stimulating substance (BCSS) that is active in the intact rat and in bone cultures. A single injection of a suspension of BCSS adjacent to the radius-ulna complex of a rat significantly increased appositional bone formation in a dose-dependent manner. The pattern of new bone deposition differed from that caused by nonspecific irritants. A suspension or water-soluble extract of BCSS significantly increased DNA and collagen synthesis in organ cultures of diaphyseal pieces of 17-day-old fetal chick tibiae. Whether or not BCSS is different from any of the other bone-derived growth factors has not been established.

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AnimalsCattleCollagenCulture TechniquesDNADose-Response Relationship, DrugGrowth SubstancesOsteogenesisRatsJournal ArticleResearch Support, Non-U.S. Gov't

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I Clark, J P Zawadsky, W Lin, R A Berg. 1988. Bone-cell-stimulating substance.. https://pubmed.ncbi.nlm.nih.gov/3191634/

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