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PubMed · 3197261

Myocardial depression in hyperdynamic endotoxemia.

H J Lubbesmeyer·J L Theissen·S Doty·R Kimura·L Traber·D N Herndon·D L Traber
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Abstract

The presence of myocardial depression is difficult to assess in most animal models of septic shock caused by hypovolemia. We studied endotoxemia in fluid-resuscitated conscious sheep. They underwent chronic instrumentation with pulmonary artery, arterial, and left atrial catheters. After 1 week of recovery, 1.5 micrograms/kg of endotoxin (LPS) was administered intravenously over a period of 30 min. One group of nine sheep stayed on baseline fluids (2 ml/kg/h of Ringer's lactate), while a second group (n = 6) was resuscitated with 7 ml/kg/h Ringer's lactate solution over the 24-h study period. Both groups were compared with controls. Eight hours after LPS, left ventricular stroke work index was depressed in both groups. In the group resuscitated with 7 ml/kg Ringer's lactate this depression associated with a normal left atrial pressure and a constant peripheral resistance indicated a shift in the Starling work curve downward and to the right evidencing myocardial depression.

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AnimalsEndotoxinsFemaleHeartHemodynamicsOxygenResuscitationSheepShock, SepticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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H J Lubbesmeyer, J L Theissen, S Doty, R Kimura, L Traber, D N Herndon, D L Traber. 1988. Myocardial depression in hyperdynamic endotoxemia.. https://pubmed.ncbi.nlm.nih.gov/3197261/

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