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A general approach to selection of multiple cubic volume elements using the ISIS technique.

R J Ordidge·R M Bowley·G McHale
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Abstract

The ISIS method is used regularly for the selection of a single cubic volume of tissue for in vivo investigation by high-resolution NMR spectroscopy. This technique has been extended on a theoretical basis to include the simultaneous selection of a number of cubes, the signals from which can be either assessed individually or in certain circumstances coadded to produce improvement in signal-to-noise ratio. The modification requires additional selective RF pulses in the spatial encoding prepulse period, and spatially localized spectra are produced by addition and subtraction of NMR signals in a manner similar to the original ISIS technique.

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R J Ordidge, R M Bowley, G McHale. 1988. A general approach to selection of multiple cubic volume elements using the ISIS technique.. https://doi.org/10.1002/mrm.1910080309

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