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PubMed · 320663

Functional specificity of thymus- dependent lymphocytes.

W E Paul·B Benacerraf
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Abstract

Thymus-dependent lymphocytes display a restricted range of specificity when compared to thymus-independent (B) lymphocytes. They react particularly to thymus-dependent protein and cell surface antigens and to products of genes encoded in the MHC. In addition, T lymphocytes have important functions in regulating the immune response and in discriminating of self from nonself. Recent work indicates that individual T lymphocytes possess receptors that interact with both thymus-dependent antigens and MHC gene products, either independently or as associated structures. We attempt to relate this complex specificity pattern to the regulatory and surveillance functions of T lymphocytes.

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AnimalsAntibody FormationAntigensB-LymphocytesBinding SitesClone CellsCytotoxicity Tests, ImmunologicGenesGenetic LinkageHistocompatibility AntigensHumansHypersensitivity, DelayedImmunity, CellularImmunoglobulin AllotypesImmunoglobulin GImmunoglobulin MImmunologic MemoryImmunosuppression TherapyLymphocyte ActivationMacrophagesT-LymphocytesJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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W E Paul, B Benacerraf. 1977-03-25. Functional specificity of thymus- dependent lymphocytes.. https://doi.org/10.1126/science.320663

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