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Decrease of rapid-eye-movement sleep in the light by intraventricular application of a VIP-antagonist in the rat.

M Mirmiran·J Kruisbrink·N P Bos·D Van der Werf·G J Boer
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Abstract

Vasoactive intestinal polypeptide (VIP) has been shown to increase the amount of time spent in rapid-eye-movement (REM) sleep both in cats and in rats. In the present study we examined the effect of a newly available competitive VIP-antagonist ([4Cl-D-Phe6-Leu17]-VIP) on sleep-wake patterns in male rats during both the light and the dark phase of 24 h. Continuous intracerebroventricular application of this VIP-antagonist reduced by 44% the amount of time spent in REM sleep during the light period. It is concluded that VIP may play a role in the generation and maintenance of REM sleep.

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AnimalsCerebral VentriclesInjections, IntraventricularRatsRats, Inbred StrainsReference ValuesSleep, REMVasoactive Intestinal PeptideJournal Article

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M Mirmiran, J Kruisbrink, N P Bos, D Van der Werf, G J Boer. 1988-08-16. Decrease of rapid-eye-movement sleep in the light by intraventricular application of a VIP-antagonist in the rat.. https://doi.org/10.1016/0006-8993(88)90516-1

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