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The incretin concept today.

W Creutzfeldt
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Abstract

1. The insulinogenic factor of the gastrointestinal mucosa named "incretin" is only one part of the complex enteroinsular axis. --2. Of the chemically defined gastrointestinal hormones GIP is the strongest incretin candidate. --3. Because of the dual function of GIP as gastrone and insulinotropic substance several safeguards against GIP-mediated insulin hypoglycaemia exist. --4. No pathological condition has yet been found which is causally related to hyper- or hyposecretion of GIP. However, an exaggerated GIP response (usually secondary to the disease) may participate in the pathogenesis of hyperinsulinaemia of patients with obesity and duodenal ulcer. --5. The injection of GIP antibodies only partially abolishes the incretin effect. Therefore, GIP, although important, is not the only incretin.

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AbsorptionDiabetes MellitusFeedbackGastrinsGastrointestinal HormonesHumansInsulinInsulin SecretionNeurotransmitter AgentsObesityPeptidesVagus NerveJournal ArticleReview

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W Creutzfeldt. 1979. The incretin concept today.. https://doi.org/10.1007/bf01225454

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