Efficient oligoadenylate synthesis catalyzed by uranyl ion complex in aqueous solution.

H Sawai; K Kuroda; T Hojo

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PubMed · 3226922

Efficient oligoadenylate synthesis catalyzed by uranyl ion complex in aqueous solution.

H Sawai·K Kuroda·T Hojo

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Abstract

Polymerization of adenosine-5'-phosphorimidazolide in an aqueous solution was conducted with uranyl ion as a catalyst. Oligoadenylate formation took place efficiently with high regio-selectivity (2'-5' linkage). The oligoadenylates up to hexadecamer were obtained in a high total yield. The chain length and the regio-selectivity of the resulting oligoadenylates varied greatly depending on the concentration of the uranyl ion catalyst. The oligonucleotide formation is likely to be mediated by uranylnucleotide complex.

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Adenine Nucleotides Chromatography, High Pressure Liquid Indicators and Reagents Oligoribonucleotides Solutions Uranium Journal Article

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H Sawai, K Kuroda, T Hojo. 1988. Efficient oligoadenylate synthesis catalyzed by uranyl ion complex in aqueous solution.. https://pubmed.ncbi.nlm.nih.gov/3226922/

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