Software review: Dioptimum.

P S Binder

PubMed · 3228969

Software review: Dioptimum.

Abstract

UNLABELLED: BEST FEATURES: The software screens all preoperative measurements to detect those likely to be in error. This data screening function is based on statistical analysis of the distribution of eye measurements within the human population. If measurements are input that are far from the average value, the program will identify those cases with a message on the screen and a large warning sign. Nevertheless, the program will perform the requested lens power calculations. The program will also compare measurements between right and left eyes, if both are entered, and a test is performed on the asymmetry between the eyes. WORST FEATURES: The lack of a written owner's manual is probably the most glaring defect of the program, even though most of the important information is present on a disk. Only users familiar with running software programs will be able to easily obtain the data. The program can be installed on a hard disk only two times. For physicians with multiple offices or multiple computers that are not on-line, this is a significant handicap. HARDWARE REQUIREMENTS: Two floppy disk drives, 256K RAM and printer, DOS 3.0 or higher are required. One floppy drive plus a hard drive can also be used. The program will run a TTL monochrome or color monitor but the type of color monitor is not specified. LIST PRICE: $495 COPY PROTECTION: Yes USER SUPPORT: 800 number available EASE OF USE: Good ON SCREEN HELP: Yes CONSUMER VALUE: Very expensive PERFORMANCE: Excellent PUBLISHED BY: Storz Ophthalmics, Inc. 1365 Hamlet Avenue Clearwater, FL 34616 (818)-443-2606 or (800)-237-5906 A defective disk can be returned for replacement at no charge within 1 year of the date of purchase. Beyond that date, disks can be replaced at a cost of $10.00. In summary, this is a very well thought out software program for calculating and printing IOL powers using a second-generation lens implant power formula. With appropriate written documentation, the program will become extremely easy to use, even for novices. Because it is so simple to use, surgeons will continually update their personalized surgeon factors and patient data in order to provide patients with the best possible refractive results. A discussion of the use of the Holladay formula in comparison to other formulas is found in reference 2.

Explore related subjects

Humans Lenses, Intraocular Mathematical Computing Optics and Photonics Software Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

P S Binder. Software review: Dioptimum.. https://pubmed.ncbi.nlm.nih.gov/3228969/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2027

Global Genomic Surveillance.

Global genomic surveillance has emerged as a foundational pillar of public health in the twenty-first century, enabling real-time tracking of pathogen evolution and informing outbreak response. This chapter examines the strategic architecture of global genomic surveillance, focusing on its application to arboviruses such as chikungunya virus (CHIKV). It explores the integration of genomic data with epidemiological, clinical, and environmental information within a One Health framework, while addressing critical challenges in governance, equity, and interoperability. The discussion covers the entire genomic surveillance workflow, from sample collection and sequencing to bioinformatic analysis and phylogenetic inference, and highlights the transformative role of artificial intelligence (AI) in predictive surveillance. By analyzing global initiatives, operational barriers, and emerging technologies, this chapter underscores the necessity of sustainable, equitable, and interoperable genomic systems to proactively address current and future infectious disease threats.

Humans↗

PubMed2027

Systematic Dissection of Key Driver Perturbation Signatures in Single Cells via ECCITE-seq.

CRISPR screens, such as expanded CRISPR-compatible cellular indexing of transcriptomes and epitopes by sequencing (ECCITE-seq), enable the simultaneous measurement of transcriptomes, gRNA identity, and cell-surface protein expression at single-cell resolution to systematically interrogate gene function. This platform provides a powerful and scalable experimental approach for validating disease-associated regulators identified by large-scale association studies and other computational methods, including network-based analyses of multi-omics data. Here, as an example application, we describe an ECCITE-seq framework to characterize the transcriptomic consequences of perturbing multiple neuronal key driver genes associated with Alzheimer's disease (AD) in human-induced pluripotent stem cell (hiPSC)-derived neurons. More broadly, by integrating customized pooled gRNA libraries with different CRISPR effectors across multiple cell types, this approach allows for the assessment of the regulatory impact of candidate genes implicated in development and disease processes.

Humans↗

PubMed2027

Identification of Genome-Wide Chromatin Structural Aberration in Cancer by Hi-C Analysis.

Aberrant three-dimensional genome organization is a hallmark of cancer, often driving oncogene activation through mechanisms such as enhancer hijacking. High-throughput chromosome conformation capture (Hi-C) maps these interactions on a genome-wide scale. Unlike earlier dilution-based methods, in situ Hi-C performs proximity ligation within intact nuclei, minimizing random ligation noise and enabling fine-scale structure detection. This chapter describes an optimized in situ Hi-C protocol tailored for cancer cell lines using MboI digestion and biotin-mediated pull-down to generate high-complexity libraries. We further outline a computational workflow that extends beyond standard topological mapping of compartments and topologically associating domains to identify cancer-specific aberrations. Specifically, we focus on detecting chromosomal rearrangements (structural variants) and characterizing the distinct circular topology of extrachromosomal DNA. This integrated experimental and analytical framework provides the necessary tools to dissect the spatial dysregulation underlying tumor evolution.

Humans↗