Improving micrograft patency.

L S Nichter; A Bindiger

doi:10.1002/micr.1920090405

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Improving micrograft patency.

L S Nichter·A Bindiger

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Abstract

To help clarify many of the controversial issues affecting early microvascular graft patency, a series of experiments was performed comparing the relative importance of graft material used alone and in conjunction with antiplatelet agents. Using a rat carotid model employing 1 cm micrografts with 1 mm luminal diameter, this study demonstrated that 1) untreated 1 mm polytetrafluoroethylene (PTFE) and human umbilical vein (HUV) micrografts have unacceptably low patency rates; 2) treatment with the antiplatelet agents indomethacin, ibuprofen, and aspirin significantly improved micrograft patency; 3) differences in patency among the three agents were not significant; and 4) PTFE had higher patency rates than HUV, although this difference did not achieve significance.

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Animals Aspirin Blood Vessel Prosthesis Carotid Artery, Internal Female Humans Ibuprofen Indomethacin Jugular Veins Microsurgery Platelet Aggregation Inhibitors Polytetrafluoroethylene Rats Rats, Inbred Strains Umbilical Veins Vascular Patency Journal Article Research Support, Non-U.S. Gov't

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L S Nichter, A Bindiger. 1988. Improving micrograft patency.. https://doi.org/10.1002/micr.1920090405

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