PubMed Health⌕ Search

PubMed · 3242711

Why do doping control labs need a tandem mass spectrometer?

Abstract

The International Olympic Committee requires a confirmation by gas chromatography/mass spectrometry for all positive doping cases. Because of the severe consequences involved they should be more specific about the required information and determine the differences allowed. The use of tandem mass spectrometry in dope control should be required before the Olympic Games in Barcelona in 1992. This article shows the power of tandem mass spectrometry in the definite identification of a drug.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

E G de Jong, R A Maes, J M van Rossum. 1988. Why do doping control labs need a tandem mass spectrometer?. https://doi.org/10.1002/bms.1200160115

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Recommended criteria for the mass spectrometric identification of target peptides and proteins (<8 kDa) in sports drug testing.

Mass spectrometry has become an invaluable tool for the identification of prohibited peptide hormones and proteins in doping control analysis. Regulatory authorities have established criteria for identifying banned drugs in doping control specimens, but these criteria do not address the specific issues for high molecular weight protein drugs such as molecular weight determination of multiply charged molecules, analysis of chemically or enzymatically derived degradation products, identification of amino acid sequence tags, etc. Technical considerations such as sample preparation methods (e.g. immunoaffinity purification), resulting analytes (e.g. intact compounds vs. chemically or enzymatically derived peptides), ionization modes, analyzer resolution, and the information provided by respective techniques are discussed in light of sports drug testing requirements using typical application examples.

Doping in Sports↗